The Rise Of GLP-1s
Glucagon-like peptide-1 (GLP-1) receptor agonists have gained notoriety as powerful tools for weight management and type 2 diabetes mellitus (T2DM) treatment. Through simulating the natural hormone produced in the gastrointestinal tract, GLP-1s stimulate insulin secretion from the pancreas and have achieved superior glycemic control. Studies have shown that some GLP-1s have achieved reductions in HbA1c and weight loss when compared to placebo. With soaring popularity through social media and Hollywood celebrity endorsements, GLP-1 demand has outstripped supply. Supply chain disruptions and limited production capacity by manufacturers have created opportunities for compounders to fill the gap with biologically identical formulations. Compounding offers several advantages for individuals seeking GLP-1s.
The compounding solution
Compounding pharmacies offer a unique solution to the rising demand for GLP-1 medications. These specialized pharmacies can prepare formulations with various dosages not available with name brands. Using active pharmaceutical ingredients (API), these formulations are nearly identical to commercial products. During preparation, excipients can be modified to accommodate individualized allergies and sensitivities, improving drug delivery and safety efficacy.
Improved accessibility
Compounding pharmacies can offer on-demand GLP-1 medications, providing more flexibility and convenience. Patients taking these medications can receive monthly refills directly shipped from the pharmacy, maintaining a consistent supply without interruptions. This valuable option eliminates the need for frequent pharmacy visits, saving time and effort.
The cost-effective benefits
Affordability is a key component of compounded GLP-1s. Name-brands are expensive and cost-prohibitive for many, limiting necessary access to treatment. Compounding pharmacies are able to keep overhead costs down, as well as distribution expenses that larger pharmaceutical companies have. Direct sourcing of APIs also eliminates potential intermediaries that drive up costs as well. These savings are passed on to the consumer, increasing financial accessibility to a broader range of patients.
Better formulations
GLP-1s are known to cause several side effects, including nausea, vomiting, diarrhea, constipation, and fatigue. Some GLP-1s induce nausea and vomiting in 25%-50% of patients on therapy. Some animal studies have demonstrated that compounded GLP-1 versions with added vitamin B12 can potentially reduce these side effects by deactivating vomiting centers in the brain. In addition, some GLP-1s can increase the risk of vitamin B12 deficiencies by slowing gastric emptying time, so combining therapies can help reduce the risk.
Compounded GLP-1s: a better alternative
GLP-1 medication use has skyrocketed in recent years due to overall effectiveness in treating T2DM and obesity. GLP-1s were placed on the US Food and Drug Administration (FDA) short list and provided a steady demand coupled with supply chain manufacturing disruptions, enabling compounding pharmacies to meet the growing demand. Compounding offers several advantages, including improved accessibility, affordability, and the potential to reduce side effects. Through customized preparations and addressing individual patient needs, compounded GLP-1s can provide a more effective and personalized treatment option.
