Why Is GLP-1 Unique?
Glucagon-like peptide-1 receptor agonists (GLP-1s) have emerged as a highly effective class of medications for weight loss. Emulating the naturally occurring gastrointestinal (GI) hormone GLP-1 produced in the intestines, GLP-1s are 29 amino acid peptides that promote pancreatic insulin secretion, slow stomach emptying, and induce satiety in the brain. Most GLP-1s are highly effective at reducing body weight in overweight and obese patients. Several studies have demonstrated individuals losing as much as 16% of total body weight over the course of 68 weeks. For type 2 diabetics, the mean reduction of HbA1c from baseline was 0.6-1.6% in a post hoc analysis of over 8,000 participants.
A short supply
Governed by consumer awareness, Hollywood endorsements, and social media campaigns, GLP-1s have increased in popularity. As obesity affects 39.6% of the US population measured by a body mass index (BMI) of 30 or greater, effective weight loss management strategies have created a significant demand for GLP-1s outpacing manufacturer supply. Supply chain disruptions, cold chain management logistics, and distribution shortcomings also reduce inventory levels. Compounding pharmacies have stepped in to meet demand, enabling access for new and existing patients.
A personalized approach
Compounding is the pharmaceutical practice that involves preparing medications in a customized manner. Compounding exhibits a host of benefits. For instance, customizable strength or dosage and drug reformulation to remove nonessential ingredients such as lactose, gluten, or other excipients. Special drug formulations can be compounded for patients with certain allergies or sensitivities to commercially available products. Compound pharmacists acquire active pharmaceutical ingredients (API), the biologically active component, and mix the powder form and other ingredients based on the prescriber's orders and individual patient needs.
More accessibility and affordability
By providing an alternative source to GLP-1s, compounding pharmacies have created viable solutions to accessibility for patients. For patients already taking GLP-1s for type 2 diabetes, compounding pharmacies can ensure continuity of care and uninterrupted management versus commercial counterparts. Compounded formulations are generally more affordable for budget-conscious consumers seeking glycemic control or weight loss.
Compounded GLP-1s filling the void
The GLP-1 shortage has hampered treatment for many people looking for better diabetes control, weight loss, or a combination of the two. As a promising solution, compounded GLP-1s can often be tailor-made for individuals addressing specific allergies or sensitivities. By reducing the cost of GLP-1s, compounders can reach more patients seeking these medications with better accessibility. As more research uncovers the unique benefits of GLP-1s, demand will grow, and compounded alternatives will continue to bridge the gap.
